Ferrostatin-1

Inhibits ferroptosis, an iron-dependent form of nonapoptotic cell death. Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices. Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells. Inhibits oxidative lipid damage and cell death in diverse disease models. Prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species.