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Fenofibrate

ALX-270-481

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PPARα activator

Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist (EC₅₀=18µM for mouse and EC₅₀=30µM for human PPARα). Also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ (up to EC₅₀=100µM).

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Product Details

Alternative Name	2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic acid 1-methylethyl ester, Procetofen
Appearance	White to off-white crystalline solid.
CAS	49562-28-9
Couple Target	PPAR
Couple Type	Activator, Ligand
Formula	C₂₀H₂₁ClO₄
MI	14: 3978
MW	360.8
Purity	≥98% (GC)
RTECS	UA2453400
Solubility	Soluble in acetone, ether, DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis and elongation in mice: M.H. Oosterveer, et al.; J. Biol. Chem. 284, 34036 (2009), Abstract
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008), Abstract — Full Text
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006), Abstract — Full Text
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006), Abstract — Full Text
Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999), Abstract
Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981), Abstract