FCCP

BML-CM120

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MPTP inhibitor

A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 µM) depolarization and apoptosis.

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Product Details

Alternative Name	Carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone
Appearance	Yellow solid.
CAS	370-86-5
Couple Target	MPTP
Couple Type	Inhibitor
Formula	C₁₀H₅F₃N₄O
Identity	Determined by 1H-NMR.
MW	254.2
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Assessment of Protective Effects of DTPA, NAC, and Taurine on Possible Cytotoxicity Induced by Individual and Combined Zinc Oxide and Copper Oxide Nanoparticles in SH-SY5Y Cells: D. Paslı, et al.; Biol. Trace Elem. Res. 203, 153 (2025), Abstract
Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease: Zeng, J., Acin-Perez, R., et al.; Nat. Commun. 14, 2573 (2023), Abstract
Autophagy deficiency abolishes liver mitochondrial DNA segregation: K. Tostes, et al.; Autophagy 1080, 15548627 (2022), Abstract
Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts: D.M. Booth, et al.; STAR Protoc. 3, 101119 (2022), Abstract — Full Text
Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome: I.A. Khatib, et al.; J. Biol. Chem. 298, 102420 (2022), Abstract
NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling: Szczepanski, H. E., Flannigan, K. L., et al.; FASEB J. 36, e22609 (2022), Abstract
ATPase Inhibitor Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ: Pavez-Giani, M., Sánchez-Aguilera, P., et al.; Preprints.org , (2021)
Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue: Ngo, J., Benador, I. Y., et al.; STAR Protoc. 2, 100243 (2021), Abstract
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ: Pavez-Giani, M. G., Sánchez-Aguilera, P. I., et al.; Int. J. Mol. Sci. 22, (2021), Abstract
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells 10, 2265 (2021), Abstract

Last modified: May 29, 2024

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FCCP

BML-CM120

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