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Fas (human) monoclonal antibody (blocking) (SM1/23)

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This antibody is covered by our Worry-Free Guarantee.

Alternative Name	CD95, APO-1, TNFRSF 6
Application	Flow Cytometry, FUNC
Application Notes	Functional Application: blocks induction of apoptosis induced by clone SM1/1 (Prod. No. ALX-805-008) or other commercial anti-Fas antibodies.
Clone	SM1/23
Formulation	Liquid. In PBS, pH 7.2-7.4.
Host	Mouse
Immunogen	Human Fas (CD95; APO-1).
Isotype	IgG2b
Purity Detail	Protein A affinity purified.
Species Reactivity	Human
UniProt ID	P25445
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Regulatory Status	RUO – Research Use Only

Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival: Losada, A., Muñoz-Alonso, M. J., et al.; Br. J. Cancer 119, 1410 (2018), Abstract
Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis: Jiang, W., Chai, N. R., et al.; J. Immunol. 187, 781 (2011), Abstract
The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism: Chiarini, F., Del Sole, M., et al.; Leukemia 22, 1106 (2008), Abstract
Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation.: Lahesmaa, R., Nyman, T. A., et al.; Mol. Cell. Proteomics 6, 238 (2007), Application(s): Neutralization / Reactant(s): Human, Abstract

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