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Topoisomerase inhibitor. p53 activator.
Antitumor reagent. Topoisomerase II inhibitor. Induces apoptosis by FasL. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells.
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Product Details
| Alternative Name |
4-Desmethylepipodophyllotoxin 9-(4,6-O-ethylidene)-β-D-glucopyranoside, VP-16-213 |
|---|---|
| Appearance |
White to off-white powder. |
| CAS |
33419-42-0 |
| Couple Target |
p53, Topoisomerase |
| Couple Type |
Activator, Inhibitor |
| Formula |
C29H32O13 |
| MI |
14: 3886 |
| MW |
588.6 |
| Purity |
≥95% (HPLC) |
| RTECS |
KC0190000 |
| Solubility |
Soluble in DMSO, dimethyl formamide, ethyl ether or chloroform:methanol (1:1); slightly soluble in methanol or acetone; insoluble in water. |
| Source |
Semisynthetic derivative of podophyllotoxin. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C. |
|---|---|
| Handling |
Protect from light and moisture. |
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Pregnancy-associated plasma protein-A (PAPP-A) is a key component of an interactive cellular mechanism promoting pulmonary fibrosis: L.K. Bale, et al.; J. Cell. Physiol. , (2022), Abstract
- Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin: H. Sprenger, et al.; Food Chem. Toxicol. 166, 113212 (2022), Abstract
- Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury: T.G. Aubrecht, et al.; Cell Death Dis. 9, 1121 (2018), Abstract — Full Text
- 6mer seed toxicity in tumor suppressive microRNAs: Gao, Q. Q., Putzbach, W. E., et al.; Nat. Commun. 9, 4504 (2018), Abstract
- 6mer Seed Toxicity Determines Strand Selection in miRNAs: Gao, Q. Q., Putzbach, W. E., et al.; bioRxiv , (2018)
- Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract
- Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages: C.Y. Taabazuing, et al.; Cell Chem. Biol. 24, 507 (2017), Abstract — Full Text
- DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis: Okondo, M. C., Johnson, D. C., et al.; Nat. Chem. Biol. 13, 46 (2017), Abstract
- Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death: Martin, R., Desponds, C., et al.; Cell Death Discov. 2, 16024 (2016), Abstract
- A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress: Aguileta, M. A., Rojas-Rivera, D., et al.; Cell Death Differ. 23, 1670 (2016), Abstract
- The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death: F. J. Bock, et al.; Sci. Rep. 5, 11268 (2015), Application(s): Cell Culture, Abstract — Full Text
- Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II: M. Liu, et al.; J. Biol. Chem. 290, 14418 (2015), Application(s): Cell Culture, Abstract — Full Text
- Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma: Saha, M. N., Jiang, H., et al.; PLoS One 7, e30215 (2012), Abstract
- PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling: Ando, K., Kernan, J. L., et al.; Mol. Cell 47, 681 (2012), Abstract
- The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases: M. Rebsamen, et al.; Cell Death Differ. 15, 1804 (2008), Abstract
- Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway: Habermehl, D., Kammerer, B., et al.; BMC Cancer 6, 14 (2006), Abstract
- Etoposide, topoisomerase II and cancer: E.L. Baldwin & N. Osheroff; Curr. Med. Chem. Anticancer Agents 5, 363 (2005), Review, Abstract
- Etoposide: discovery and medicinal chemistry: P. Meresse, et al.; Curr. Med. Chem. 11, 2443 (2004), Review, Abstract
- Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis: C.A. Johnson, et al.; J. Biol. Chem. 276, 4539 (2001), Abstract — Full Text
- Cell cycle phase specificity in the potentiation of etoposide-induced DNA damage and apoptosis by KN-62, an inhibitor of calcium-calmodulin- dependent enzymes: M. Aoyama, et al.; Biochem. Pharmacol. 61, 49 (2001), Abstract
- In vitro topo II-DNA complex accumulation and cytotoxicity of etoposide in leukaemic cells from patients with acute myelogenous and chronic lymphocytic leukaemia: Y. Wang, et al.; Leuk. Res. 25, 133 (2001), Abstract
- Early caspase activation in leukemic cells subject to etoposide-induced G2-M arrest: evidence of commitment to apoptosis rather than mitotic cell death: R.J. Sleiman & B.W. Stewart; Clin. Cancer Res. 6, 3756 (2000), Abstract — Full Text
- Etoposide-induced apoptosis is not associated with the fas pathway in acute myeloblastic leukemia cells: T. Siitonen, et al.; Leuk. Res. 24, 281 (2000), Abstract
- Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells: M. Sawada, et al.; Cell Death Differ. 7, 761 (2000), Abstract
- Distinct pathways for stimulation of cytochrome c release by etoposide: J.D. Robertson, et al.; J. Biol. Chem. 275, 32438 (2000), Abstract — Full Text
- A systematic review of the role of etoposide and cisplatin in the chemotherapy of small cell lung cancer with methodology assessment and meta-analysis: C. Mascaux, et al.; Lung Cancer 30, 23 (2000), Abstract
- Etoposide sensitivity of human prostatic cancer cell lines PC-3, DU 145 and LNCaP: M. Salido, et al.; Histol. Histopathol. 14, 125 (1999), Abstract
- Etoposide: four decades of development of a topoisomerase II inhibitor: K.R. Hande; Eur. J. Cancer 34, 1514 (1998), Abstract
- Review of current clinical experience with prolonged (oral) etoposide in cancer treatment: R.S. de Jong, et al.; Anticancer Res. 15, 2319 (1995), Abstract
- Etoposide: twenty years later: J.D. Hainsworth & F.A. Greco; Ann. Oncol. 6, 325 (1995), Abstract
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