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Ethacrynic acid

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GST inhibitor

Inhibits LTC₄ biosynthesis by inhibition of glutathione S-transferase (GST). Inhibits 15-hydroxyprostaglandin dehydrogenase.

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Alternative Name	2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxyacetic acid
Appearance	Off-white to white.
CAS	58-54-8
Couple Target	GST
Couple Type	Inhibitor
MW	303.1
Purity	≥98%
Solubility	Soluble in 100% ethanol (35mg/ml) or DMSO (35mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo: Rastogi, A., Clark, C. W., et al.; Redox Biol. 26, 101235 (2019), Abstract
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate: J. H. T. M. Ploemen, et al.; Biochem. Pharmacol. 40, 1631 (1990), Abstract
Selective inhibition of leukotriene C4 synthesis in human neutrophils by ethacrynic acid: K. H. Leung, et al.; Biochem. Biophys. Res. Commun. 137, 195 (1986), Abstract

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