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Erythromycin

ALX-380-274

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Antibiotic

Macrolide antibiotic. Inhibits protein synthesis (elongation) at the transpeptidation step. Binds to the 23S RNA of the 50S ribosomal subunit. Effective against Gram-negative and Gram-positive bacteria.

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Product Details

Appearance	White to off-white powder.
CAS	114-07-8
Couple Target	Ribosome
Couple Type	Ligand
Formula	C₃₇H₆₇NO₁₃
MI	14: 3681
MW	733.9
Purity	≥85% (Assay on dry basis)
RTECS	KF4375000
Solubility	Soluble in water (50mg/ml), 100% ethanol or methanol.
Source	Isolated from Streptomyces erythreus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism: T. Tokairin, et al.; Br. J. Clin. Pharmacol. 60, 172 (2005), Abstract — Full Text
Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells: Y. Aoki & P.N. Kao; Antimicrob. Agents Chemother. 43, 2678 (1999), Abstract — Full Text
Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban: J.Q. Tran, et al.; J. Clin. Pharmacol. 39, 513 (1999), Abstract
Inducible erythromycin resistance in bacteria: B. Weisblum; Br. Med. Bull. 40, 47 (1984), Abstract

Last modified: May 29, 2024

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Erythromycin

ALX-380-274

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Handling & Storage

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