Epithelial sodium channel (γ-subunit, neoepitope) monoclonal antibody (11-35-1)

The epithelial sodium channel (ENaC) of the kidney is necessary for extracellular volume homeostasis and normal arterial BP. Activity of ENaC is enhanced by proteolytic cleavage of the γ-subunit. In the γ-subunit, putative cleavage sites for prostasin, kallikrein (similar site as prostasin), elastase, and plasmin exist. Prostasin is a glycosylphosphatidylinositol anchored apical serine protease expressed in the collecting duct that activates γENaC at a site close to but in the C-terminal direction to the furin cleavage with putative release of a 43-residue inhibitory tract.