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Enniatin B

ALX-380-007

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Ionophore antibiotic

Ionophore antibiotic. Inhibitor of the S. cerevisiae ABC transporter Pdr5p.Inhibitor of acyl-CoA-cholesterol acyltransferase and of phosphodiesterase. Potential anticancer compound.

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Product Details

Appearance	White to off-white crystalline solid.
CAS	917-13-5
Couple Target	ACAT, MDR, PDE
Couple Type	Inhibitor
Formula	C₃₃H₅₇N₃O₉
MI	14: 3585
MW	639.8
Purity	≥90% (HPLC)
Solubility	Soluble in DMSO or other organic solvents; almost insoluble in water.
Source	Isolated from Fusarium orthoceras var. enniatum.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Beauvericin and enniatin B effects on a human lymphoblastoid Jurkat T-cell model: L. Manyes, et al.; Food Chem. Toxicol. 115, 127 (2018), Abstract
Toxic indole alkaloids avrainvillamide and stephacidin B produced by a biocide tolerant indoor mold Aspergillus westerdijkiae: R. Mikkola, et al.; Toxicon. 99, 58 (2015), Application(s): Cell Culture , Abstract
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p: Hendrych, T., Kodedová, M., et al.; Biochim. Biophys. Acta 1788, 717 (2009), Abstract
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells: R. Dornetshuber, et al.; Chem. Res. Toxicol. 20, 465 (2007), Abstract
Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae: K. Hiraga, et al.; Biochem. Biophys. Res. Commun. 328, 1119 (2005), Abstract
Interaction of cyclic peptides and depsipeptides with calmodulin: K.A. Mereish, et al.; Pept. Res. 3, 233 (1990), Abstract
Sandwich” complexation in cyclopeptides and its implications in membrane processes”””: V.T. Ivanov; Ann. N. Y. Acad. Sci. 264, 221 (1975), Abstract
Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria: E. Gaumann, et al.; Experientia 3, 202 (1947)

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Enniatin B

ALX-380-007

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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