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Enniatin A

ALX-380-310

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Ionophore antibiotic

Ionophore antibiotic. Potential anticancer compound.

Enniatins are a family of depsipeptides produced by several species of the filamentous fungus Fusarium. Enniatins have initially been shown to act as ionophores. Later, their effects on acyl-CoA cholesterol transferase, ABC-transporters and the selectivity of their antitumor action came to the fore.

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Product Details

Appearance	White to off-white crystalline solid.
CAS	2503-13-1
Formula	C₃₆H₆₃N₃O₉
Identity	Identity determined by 1H-NMR, 13C-NMR and MS.
MI	14: 3585
MW	681.9
Purity	≥97% (HPLC)
Solubility	Soluble in 100% ethanol, methanol, DMSO and dimethyl formamide; almost insoluble in water.
Source	Isolated from Fusarium sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Fate of Fusarium Toxins during Brewing: K. Habler, et al.; J. Agric. Food Chem. 64, 190 (2017), Abstract
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction: R. Dornetshuber et al.; Mol. Nutr. Food Res. 53, 1112 (2009), Abstract
Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin: R. Dornetshuber et al.; Mol. Nutr. Food Res. 53, 904 (2009), Abstract
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation: W. Wätjen et al.; Mol. Nutr. Food Res. 53, 431 (2009), Abstract
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells: R. Dornetshuber, et al.; Chem. Res. Toxicol. 20, 465 (2007), Abstract
Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum: L. Ivanova et al.; Toxicon 47, 868 (2006), Abstract
Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae: K. Hiraga, et al.; BBRC 328, 1119 (2005), Abstract
Interaction of cyclic peptides and depsipeptides with calmodulin: K.A. Mereish, et al.; Pept. Res. 3, 233 (1990), Abstract
Sandwich” complexation in cyclopeptides and its implications in membrane processes”””: V.T. Ivanov; Ann. N. Y. Acad. Sci. 264, 221 (1975), Abstract

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Enniatin A

ALX-380-310

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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