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Product Details
| Alternative Name |
ET-1 |
|---|---|
| CAS |
117399-94-7 |
| Formula |
C109H159N25O32S5 |
| Formulation |
Lyophilized. |
| MI |
14: 3576 |
| MW |
2492.0 |
| Purity |
≥98% (HPLC) |
| Quantity |
*Sold as net peptide weight. |
| RTECS |
KE9446500 |
| Sequence |
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH |
| Solubility |
1mg/ml soluble in DMSO or 5% acetic acid. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Solution is stable for 1-2 weeks when stored at -20°C. Prepare solution just before use. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Immunomodulatory imide drugs inhibit human detrusor smooth muscle contraction and growth of human detrusor smooth muscle cells, and exhibit vaso-regulatory functions: Tamalunas, A., Wendt, A., et al.; Biomed. Pharmacother. 177, 117066 (2024), Abstract
- Effects of carvedilol on human prostate tissue contractility and stromal cell growth pointing to potential clinical implications: Hu, S., Muderrisoglu, A. E., et al.; Pharmacol. Rep. 76, 807 (2024), Reactant(s): Human, Abstract
- Increased Risk for Atrial Alternans in Rabbit Heart Failure: The Role of Ca2+/Calmodulin-Dependent Kinase II and Inositol-1,4,5-trisphosphate Signaling: G. Kanaporis, et al.; Biomolecules 14, 53 (2024), Abstract
- Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729: R. Huang, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 395, 471 (2022), Abstract
- Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells: A. Tamalunas, et al.; Life Sci. 308, 120931 (2022), Abstract
- Lenalidomide and pomalidomide inhibit growth of prostate stromal cells and human prostate smooth muscle contraction: A. Tamalunas, et al.; Life Sci. 281, 119771 (2021), Abstract
- Endothelin-1 enhanced carotid body chemosensory activity in chronic intermittent hypoxia through PLC, PKC and p38MAPK signaling pathways: J. Li, et al.; Neuropeptides 74, 44 (2019), Abstract
- Interactions of peripheral endothelin-1 and nerve growth factor as contributors to persistent cutaneous pain.: A. Khodorova, et al.; Physiol. Res. 67, S215 (2018), Reactant(s): Rat, Abstract — Full Text
- Prostanoid EP2 Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells: J.A. Patel, et al.; Int. J. Mol. Sci. 18, 2372 (2018), Abstract — Full Text
- Role of endothelin‑1 and its receptors in cerebral vasospasm following subarachnoid hemorrhage: Y.W. Cheng, et al.; Mol. Med. Rep. 18, 5229 (2018), Abstract
- Mandibular Explant Assay for Investigating Extrinsic Stimuli on Bone and Cartilage Development: J. Jiang, et al.; Bio Protoc. 7, e2641 (2017), Abstract — Full Text
- Cloning and sequencing of a bovine preproendothelin cDNA: G.J. Price & L. Malone; Nucleic Acids Res. 18, 3658 (1990), Abstract
- The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes: A. Inoue, et al.; PNAS 86, 2863 (1989), Abstract
- Molecular biology and biochemistry of the endothelins: M. Yanagisawa & T. Masaki; TIPS 10, 374 (1989), Abstract
- A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]: M. Yanagisawa, et al.; Nature 332, 411 (1988), Abstract
- Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin: Y. Itoh, et al.; FEBS Lett. 231, 440 (1988), Abstract
- Synthesis and disulfide structure determination of porcine endothelin: an endothelium-derived vasoconstricting peptide: S. Kumagaye, et al.; Int. J. Pept. Prot. Res. 32, 519 (1988), Abstract
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