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Elaiophylin

ALX-380-212

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Inhibitor of testosterone 5-reductase and P-ATPase

Macrolide antibiotic inhibiting testosterone 5-reductase and plasma-proton ATPase (P-ATPase). Shows antifungal, antiprotozoal, antitumor, antihelmintic and immunosuppressive activity.

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Product Details

Alternative Name	Antibiotic 255-E, Antibiotic 5001B, Antibiotic 56-62, Antibiotic 846 I, SNA 4606-3, Azalomycin B, Gopalamicin, Salbomycin
Appearance	White to off-white solid.
CAS	37318-06-2
Couple Target	ATPase, Testosterone 5-reductase
Couple Type	Inhibitor
Formula	C₅₄H₈₈O₁₈
Identity	Determined by 1H-NMR.
MW	1025.3
Purity	≥95% (HPLC)
RTECS	CL8380000
Solubility	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Source	Isolated from Streptomyces sp. MT-1.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C.
Handling	Protect from light when in solution.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Time lapse imaging analysis of the effect of ER stress modulators on apoptotic cell assessed by caspase3/7 activation in NG108-15 cells: A. Saito, et al.; Data Brief 6, 20 (2015), Application(s): Cell culture, Abstract
In vitro and in vivo antiprotozoal activities of bispolides and their derivatives: K. Otoguro, et al.; J. Antibiot. (Tokyo) 63, 275 (2010), Abstract
Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes: P.A. Grigoriev, et al.; Bioelectrochemistry 54, 11 (2001), Abstract
Elaiophylins, new cell cycle inhibitors and apoptosis inducers, produced by Streptomyces pseudoverticillus II. Structures and biological properties.: C. Cui, et al.; Chinese J. Antibiot. 26, 165 (2001)
Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin: A. Fang, et al.; J. Antibiot. (Tokyo) 53, 158 (2000), Abstract
SNA-4606-1, a new member of elaiophylins with enzyme inhibition activity against testosterone 5 alpha-reductase: M. Nakakoshi, et al.; J. Antibiot. (Tokyo) 52, 175 (1999), Abstract
Elaiophylin as a rumen fermentation efficiency enhancer: C.M. Liu, et al.; J. Antibiot. (Tokyo) 46, 350 (1993), Abstract
Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger: H.P. Fiedler, et al.; J. Antibiot. (Tokyo) 34, 1107 (1981), Abstract
Melanosporin and elaiophylin, new antibiotics from Streptomyces malanosporus (sive melanosporofaciens) n. sp.: F.M. Arcamone, et al.; G. Microbiol. 7, 207 (1959)

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Elaiophylin

ALX-380-212

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Handling & Storage

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