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Eicosapentaenoic acid

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Inhibits PGE2 formation

Beneficial effect in cardiovascular diseases and inflammation. Inhibits PGE₂ formation from arachidonic acid in 3T3 fibroblats.

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Alternative Name	Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic acid (20:5, n-3), Icosapent
Appearance	Colorless oil.
CAS	10417-94-4
Couple Target	Prostaglandin E2
Couple Type	Inhibitor
Formula	C₂₀H₃₀O₂
MW	302.5
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. After opening, store under an inert atmosphere (e.g. N2 or argon) at -80°C. Stock solutions are stable for up to 2 months at -80°C under an inert atmosphere.
Handling	Protect from air.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Differential effects of n-6 and n-3 polyunsaturated fatty acids on cell growth and early gene expression in Swiss 3T3 fibroblasts: U. Danesch, et al.; J. Cell. Physiol. 168, 618 (1996), Abstract
Eicosapentaenoic acid: its relevance in atherosclerosis and coronary artery disease: J. Mehta, et al.; Am. J. Cardiol. 59, 155 (1987), Abstract
Eicosapentaenoic acid as a modulator of inflammation. Effect on prostaglandin and leukotriene synthesis: T. Terano, et al.; Biochem. Pharmacol. 35, 779 (1986), Abstract
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function: T.H. Lee, et al.; N. Engl. J. Med. 312, 1217 (1985), Abstract

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