EHNA

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PDE inhibitor

Phosphodiesterase PDE II inhibitor, IC₅₀=0.8 µM. Also inhibits adenosine deaminase, K_i=4 nM.

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Alternative Name	Erythro-9-(2-hydroxy-3-nonyl)adenine . HCl
Appearance	White solid.
CAS	51350-19-7
Couple Target	Adenosine Deaminase, PDE
Couple Type	Inhibitor
Formula	C₁₄H₂₃N₅O . HCl
MW	313.8
Purity	≥98% (HPLC)
Solubility	Soluble in water (25mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells: Tinsley, H. N., Gary, B. D., et al.; Cancer Prev. Res. (Phila) 4, 1275 (2011), Abstract
Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine: T. Podzuweit, et al.; Cell. Signal. 7, 733 (1995), Abstract
Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes: P.F. Mery, et al.; Mol. Pharmacol. 48, 121 (1995), Abstract
Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition: M. Bessodes, et al.; Biochem. Pharmacol. 31, 879 (1982), Abstract

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