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EDA-A1 (soluble) (human), (recombinant)

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Alternative Name	Ectodysplasin-A1
Application Notes	ELISA: binds to EDAR.
Concentration	0.1mg/ml after reconstitution.
Endotoxin Content	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
Formulation	Lyophilized. Contains PBS.
MW	~20kDa (SDS-PAGE).
Purity	≥95% (SDS-PAGE)
Reconstitution	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Source	Produced in E. coli. The extracellular domain of human EDA-A1 (ectodysplasin-A1) (aa 245-391) is fused at the N-terminus to a linker peptide (9 aa) and a FLAG^®-tag.
Specificity	Binds to human EDAR (ectodysplasin-A1 receptor).
UniProt ID	Q92838

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

A Missense Mutation in the Collagen Triple Helix of EDA Is Associated with X-Linked Recessive Hypohidrotic Ectodermal Dysplasia in Fleckvieh Cattle: S. Reinartz, et al.; Genes 15, 8 (2023), Abstract
Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A: P. Schneider, et al.; J. Biol. Chem. 276, 18819 (2001), Abstract — Full Text

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