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Organoselenium compound. Antioxidant.
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL). Protects cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death.
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Product Details
| Appearance |
White to off-white crystalline solid. |
|---|---|
| CAS |
60940-34-3 |
| Couple Target |
COX, Lipoxygenase, NADPH, NADPH oxidase, PKC |
| Couple Type |
Inhibitor |
| Formula |
C13H9NOSe |
| Identity |
Determined by NMR. |
| MW |
274.2 |
| Purity |
≥98% (HPLC) |
| Solubility |
Soluble in DMSO or 100% ethanol. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly: Boršić, E., Ramuta, T. Ž., et al.; Nat. Commun. 16, 4887 (2025), Abstract
- A general covalent binding model between cytotoxic selenocompounds and albumin revealed by mass spectrometry and X-ray absorption spectroscopy: W. Zheng, et al.; Sci. Rep. 10, 1274 (2020), Abstract — Full Text
- Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation: S. Hamarsheh, et al.; Nat. Commun. 11, 1659 (2020), Abstract — Full Text
- Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2: J.D. Bernstock, et al.; FASEB J. 32, 1677 (2018), Abstract
- Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species: Topf, U., Suppanz, I., et al.; Nat. Commun. 9, 324 (2018), Abstract
- Differential induction of ATF3 and HO-1 in myeloid cells and keratinocytes via Dimethylfumarate or Cyclosporine A: S. Müller, et al.; J. Dermatol. Sci. 87, 246 (2017), Application(s): Treatment of human keratinocytes and PBMCs, Abstract
- Intermittent Hypoxia-Induced Carotid Body Chemosensory Potentiation and Hypertension Are Critically Dependent on Peroxynitrite Formation: Moya, E. A., Arias, P., et al.; Oxid. Med. Cell. Longev. 2016, 9802136 (2016), Abstract
- Toll-like receptor 4-mediated nuclear factor kappa B activation is essential for sensing exogenous oxidants to propagate and maintain oxidative/nitrosative cellular stress: Karki, R., Igwe, O. J., et al.; PLoS One 8, e73840 (2013), Abstract
- Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers: L. Zuo, et al.; J. Appl. Physiol. 111, 898 (2011), Abstract — Full Text
- Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998), Abstract — Full Text
- Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998), Abstract
- Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997), Abstract
- Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997), Abstract
- Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995), Abstract
- Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995), Abstract
- Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994), Abstract
- Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994), Abstract
- Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994), Abstract
- Interaction of ebselen with glutathione S-transferase and papain in vitro: T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994), Abstract
- Action of ebselen as an antioxidant against lipid peroxidation:: N. Noguchi, et al.; Biochem. Pharmacol. 44, 39 (1992), Abstract
- Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989), Abstract
- Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988), Abstract
- Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987), Abstract
- A novel biologically active seleno-organic compound–III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984), Abstract
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