Home Shop EB-47 . dihydrochloride . dihydrate

EB-47 . dihydrochloride . dihydrate

ALX-270-383

Datasheet
Manual
SDS
CofA

Already have an account?

PARP-1 inhibitor

Very potent and water soluble PARP-1 inhibitor (IC₅₀=45nM, 100% inhibition at 200nM). Shows cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	1-Piperazineacetamide,4-[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuron]-N-(2,3-dihydro-1H-isoindol-4-yl)-1-one . 2HCl . 2H2O
Appearance	White solid.
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₂₄H₂₇N₉O₆ . 2HCl . 2H₂O
Identity	Determined by 1H-NMR.
MW	537.5 . 73.0 . 36.0
Purity	≥95% (HPLC)
Solubility	Soluble in water or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Packaged under inert gas.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Potency of inhibitors, Abstract — Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1): P.G. Jagtap, et al.; Bioorg. Med. Chem. Lett. 14, 81 (2004), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

EB-47 . dihydrochloride . dihydrate

ALX-270-383

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project