E-Cadherin recombinant monoclonal antibody (032)

The anti-E-Cadherin (CDH1/CD324) antibody is specifically designed to detect E-Cadherin, a calcium-dependent cell adhesion protein critical for maintaining epithelial tissue structure and integrity.

E-Cadherin (epithelial cadherin), also known as CDH1 or CD324, is a calcium-dependent cell adhesion molecule crucial for maintaining epithelial tissue integrity and polarity. It belongs to the cadherin superfamily and mediates cell-cell adhesion through homophilic interactions, playing a central role in tissue architecture, cellular communication, and signaling. E-Cadherin is a key regulator of epithelial-to-mesenchymal transition (EMT), a process critical during embryonic development, wound healing, and cancer metastasis. Loss or dysfunction of E-Cadherin disrupts cell adhesion, contributing to increased cell motility and invasion, often correlating with poor prognosis in cancers such as breast, gastric, and ovarian carcinomas.