E-64

ALX-260-007

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Protease inhibitor

Irreversible inhibitor of cysteine proteinases like papain, calpain, cathepsin B, L and H. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases. Inhibits degradation of autophagic cargo in autophagolysosomes.

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Product Details

Alternative Name	N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine, L-trans-Epoxysuccinyl-leucylamide-(4-guanido)-butane
Appearance	White to off-white solid.
CAS	66701-25-5
Couple Target	Calpain, Cathepsin, Papain
Couple Type	Inhibitor
Formula	C₁₅H₂₇N₅O₅ . 0.5 H₂0
MW	357.4
Purity	≥98%
Solubility	Soluble in water/ethanol 1:1 mixture (15 mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation: Kunath, A., Weiner, J., et al.; Biomedicines 9, (2021), Abstract
Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog. 11, e1004725 (2015), Application(s): Cell Culture, Abstract — Full Text
Deubiquitinating enzymes regulate PARK2-mediated mitophagy: Wang, Y., Serricchio, M., et al.; Autophagy 11, 595 (2015), Abstract
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy: Wang, Y., Nartiss, Y., et al.; Autophagy 8, 1462 (2012), Abstract
Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases: M. Tamai, et al.; Chem. Pharm. Bull. (Tokyo) 35, 1098 (1987), Abstract
Isolation and Characterization of E-64, a New Thiol Protease Inhibitor: K. Hanada, et al.; Agric. Biol. Chem. 42, 523 (1978), Full Text
Structure and Synthesis of E-64, a New Thiol Protease Inhibitor: K. Hanada, et al.; Agric. Biol. Chem. 42, 529 (1978), Full Text

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Last modified: May 29, 2024

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E-64

ALX-260-007

Product Details

Handling & Storage

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