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E-4031 . dihydrochloride

BML-KC158

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K⁺ channel blocker

Potent and selective blocker of the inactivating inward rectifying potassium current IKR (HERG channel). Class III antiarrythmic agent with differential atrial vs. ventricular activity.

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Product Details

Alternative Name	4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide
Appearance	White solid.
CAS	113559-13-0
Couple Target	HERG, Potassium channel
Couple Type	Blocker
Formula	C₂₁H₂₇N₃O₃S . 2HCl . 2H₂O
MW	401.5 . 73.0 . 36.0
Purity	≥98% (HPLC)
Solubility	Soluble in any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Discovery of 1,3,4-Oxadiazole Derivatives as Broad-Spectrum Antiparasitic Agents: A. Ioana Corfu, et al.; ACS Infect. Dis. 10, 2222 (2024), Abstract
High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents: Linciano, P., Quotadamo, A., et al.; J. Med. Chem. 66, 15230 (2023), Abstract
In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o: L. Blum, et al.; Sci. Rep. 10, 7534 (2020), Abstract — Full Text
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform: Moraes, C. B., Witt, G., et al.; SLAS Discov. 24, 346 (2019), Abstract
Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates: C. Forny, et al.; J. Vis. Exp. 140, 58290 (2018), Abstract — Full Text
A Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte (hiPSC-CM) Multielectrode Array Assay for Preclinical Cardiac Electrophysiology Safety Screening: K. Harris; Curr. Protoc. Pharmacol. 71, 11.18.1 (2015), Abstract
Characterization of the effects of Ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes: M.R. Nikmaram, et al.; Prog. Biophys. Mol. Biol. 96, 452 (2008), Abstract
State dependent dissociation of HERG channel inhibitors: D. Stork, et al.; Br. J. Pharmacol. 151, 1368 (2007), Abstract
Role of reverse mode Na+/Ca2+ exchanger in the cardioprotection of metabolic inhibition preconditioning in rat ventricular myocytes: S.Z. Liu, et al.; Eur. J. Phamacol. 561, 14 (2007), Abstract
Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells: S.Y. Yeung & I.A. Greenwood; Am. J. Physiol. Cell Physiol. 292, C468 (2007), Abstract — Full Text

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E-4031 . dihydrochloride

BML-KC158

Product Details

Handling & Storage

Resources

Metabolism

Cellular Therapy

Cardiovascular Research

Drug Discovery

AMPIVIEW® RNA Probes

Immuno-Oncology

AMPIGENE® PCR Solutions

Bioprocess

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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