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DZNep hydrochloride is a potent inhibitor of the enzyme EZH2, a histone methyltransferase. This compound acts as an epigenetic modifier by blocking the trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4.
DZNep hydrochloride is also a competitive inhibitor of the Adenosylhomocysteinase (AHCY) S-adenosylhomocysteine hydrolase, with a Ki value of 50 pM. It has shown promising results in inducing selective apoptosis in cancer cells, inhibiting the self-renewal of glioblastoma multiforme cancer stem cells, and enhancing the survival of acute myeloid leukemia blast cells when used in combination with histone deacetylase inhibitors.
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RUO – Research Use Only |
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| CAS | 38966-21-1 |
|---|---|
| Couple Type | Inhibitor |
| Purity | ≥98% (TLC) |
| Alternative Name | (+)-3,3’,4’,5,7-Flavanpentol . H2O |
|---|---|
| CAS | 225937-10-0 |
| Purity | ≥98% (HPLC) |
| Alternative Name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone |
|---|---|
| CAS | 7770-78-7 |
| Couple Type | Inhibitor |
| Purity | ≥97% (HPLC) |
| Alternative Name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone |
|---|---|
| CAS | 20362-31-6 |
| Couple Type | Inhibitor |
| Purity | ≥95% (HPLC) |