DuP-697

BML-EI358

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COX inhibitor

DuP-697 is a highly selective and irreversible inhibitor of cyclooxygenase-2 (COX-2). (COX-2 IC₅₀=10nM, COX-1 IC₅₀=800nM). It is an orally effective anti-inflammatory, analgesic and antipyretic agent which is not ulcerogenic. Inhibition of COX-2 by DuP-697 and other inhibitors exacerbates ischemia-induced myocardial dysfunction in the rabbit. It inhibits angiogenesis and induces apoptosis in human endothelial cells.

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Product Details

Alternative Name	(5-Bromo-2[4-fluorophenyl]-3-[4-methylsulfonyl-phenyl]thiophene)
Appearance	White to off-white solid.
CAS	88149-94-4
Couple Target	COX
Couple Type	Inhibitor
Formula	C₁₇H₁₂BrFO₂S₂
Identity	Determined by NMR.
MW	411.3
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml) or 100% ethanol (5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697): A. Churchman, et al.; Eur. J. Pharmacol. 573, 176 (2007), Abstract
Inhibition of cyclo-oxygenase-2 exacerbates ischaemia-induced acute myocardial dysfunction in the rabbit: G. Rossoni, et al.; Br. J. Pharmacol. 135, 1540 (2002), Abstract
Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase: R.A. Copeland, et al.; PNAS USA 91, 11202 (1994), Abstract
Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor: K.R. Gans, et al.; J. Pharmacol. Exp. Ther. 254, 180 (1990), Abstract

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DuP-697

BML-EI358

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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