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ALX-280-001

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ALX-280-001-G005 — 5 g

$114.00

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ALX-280-001-G010 — 10 g

$194.00

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ALX-280-001-G025 — 25 g

$350.00

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ALX-280-001-G050 — 50 g

$572.00

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Protective agent for SH groups

Cell permeable protective agent for SH groups, maintaining monothiols completely in the reduced state and of reducing disulfides quantitatively. ER-stress inducer.

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Product Details

Alternative Name	1,4-Dithio-DL-threitol, DL-Dithiothreitol, Cleland’s Reagent
Appearance	White to off-white solid.
CAS	3483-12-3
Couple Type	Ligand
Formula	C₄H₁₀O₂S₂
Identity	Determined by IR.
MI	14: 3376
MW	154.3
Purity	≥98% (Assay by Iodometric Titration)
RTECS	EK1610000
Solubility	Soluble in water, 100% ethanol, acetone or ethyl acetate.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Very hygroscopic. Keep under inert gas.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Protocol for electroporating and isolating murine (sub)ventricular zone cells for single-nuclei omics: Holmberg, J. C., Riley, V. A., et al.; STAR Protoc. 5, 103095 (2024), Abstract
A mannosylated polymer with endosomal release properties for peptide antigen delivery: K. Song, et al.; J. Control Release 356, 232 (2023), Abstract
Tsc2 coordinates neuroprogenitor differentiation: Riley, V. A., Shankar, V., et al.; iScience 26, 108442 (2023), Abstract
Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma: K.D. Koh, et al.; Cell Genom. 3, 100229 (2022), Abstract
Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes: Fidalgo, M. F., Fonseca, C. G., et al.; Life Sci. Alliance 5, (2022), Abstract
Adrenomedullin and truncated peptide adrenomedullin(22-52) affect chondrocyte response to apoptotis in vitro: downregulation of FAS protects chondrocyte from cell death: F. Velard, et al.; Sci. Rep. 10, 16740 (2020), Abstract — Full Text
Protein tyrosine phosphatase 1B and α-glucosidase inhibitory activities of Pueraria lobata root and its constituents: S.H. Seong, et al.; J. Ethnopharmacol. 194, 706 (2016), Application(s): Inhibitory activity and enzyme kinetic analysis, coral, Abstract
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells: M. McNaughton, et al.; Oncotarget 7, 16663 (2016), Application(s): Western blot, Abstract — Full Text
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7: Y. Liu, et al.; Cell Death Dis. 6, e1630 (2015), Application(s): Assay, Abstract — Full Text
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy: L. Qin, et al.; Autophagy 6, 239 (2010), Abstract

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ALX-280-001

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