DR2313

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PARP inhibitor

Potent, water soluble competitive PARP inhibitor (IC₅₀=0.20µM and 0.24µM for PARP-1 and PARP-2 respectively).

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Alternative Name	2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
Appearance	White to off-white crystalline solid.
CAS	284028-90-6
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₈H₁₀N₂OS
MW	182.2
Purity	≥98% (HPLC (UV))
Solubility	Soluble in DMSO, methanol or water.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats: H. Nakajima, et al.; Pharmacol. Exp. Ther. 312, 472 (2005), Abstract — Full Text

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