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ALX-270-221

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PARP-1 inhibitor

Very potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor.

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Product Details

Appearance	Off-white to light brown solid.
CAS	129075-73-6
Couple Target	PARP
Couple Type	Inhibitor
Formula	C₁₈H₂₆N₂O₂
Identity	Determined by 1H-NMR.
MW	302.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions in DMSO are stable for up to 1 month when stored at -20°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export: J.M. Rodríguez-Vargas, et al.; Cell Death Differ. 23, 2007 (2016), Application(s): Cell treatment, MCF7 GFP-LC3 cells, Abstract
Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death: K. Moriwaki, et al.; Cell Death Dis. 6, e1636 (2015), Application(s): Cell Culture, Abstract — Full Text
Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP-ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells: X. Feng, et al.; Int. J. Onc. 42, 749 (2013), Abstract — Full Text
PARP inhibition attenuates histopathological lesion in ischemia/reperfusion renal mouse model after cold prolonged ischemia: del Moral, R. M., Gómez-Morales, M., et al.; ScientificWorldJournal 2013, 486574 (2013), Abstract
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy: Rodriguez-Vargas, J. M., Ruiz-Magaña, M. J., et al.; Cell Res. 22, 1181 (2012), Abstract
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways: Wang, M., Wu, W., et al.; Nucleic Acids Res. 34, 6170 (2006), Abstract
Comet assay as a novel approach for studying DNA damage in focal cerebral ischemia: differential effects of NMDA receptor antagonists and poly(ADP-ribose) polymerase inhibitors: L. Giovannelli, et al.; J. Cereb. Blood Flow Metab. 22, 697 (2002), Abstract
Poly(ADP-ribose) polymerase inhibitors attenuate necrotic but not apoptotic neuronal death in experimental models of cerebral ischemia: F. Moroni, et al.; Cell Death Differ. 8, 921 (2001), Abstract
Post-treatment with an inhibitor of poly(ADP)-ribose polymerase attenuates cerebral damage in focal ischemia: K. Takahashi, et al.; Brain Res. 829, 46 (1999), Abstract — Full Text
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion: C. Szabo & V.L. Dawson; TIPS 19, 287 (1998), (Review), Abstract

Last modified: May 29, 2024

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DPQ

ALX-270-221

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