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DPPIV (human), (recombinant)

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Highly active

DPPIV is involved in diseases such as diabetes (via cleavage of GIP and GLP-1) and cancer.

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Alternative Name	Dipeptidyl Peptidase IV, DPP4, CD26
Application Notes	Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors.
Formulation	Liquid. In 10 mM TRIS, pH 8.0, 100mM NaCl.
MW	85.4 kDa
Purity	≥95% (SDS-PAGE)
Purity Detail	Purified by multi-step chromatography.
Source	Produced in Sf9 insect cells using baculovirus expression system. Active recombinant human DPPIV (aa 29-766). This represents a naturally-occurring cleaved (soluble) form of DPPIV.
Specific Activity	One unit produces 1µmole free pNA per minute, using as substrate 100 µM H-Gly-Pro-pNA (Prod. No. BML-P188) in 50mM TRIS pH 7.5 at 37°C.
UniProt ID	P27487

Use/Stability	The enzyme is stable on ice for at least several hours. However, it is recommended that thawing and dilution of the enzyme be done within as short a time as possible before start of the assay. After initial defrost, the remaining, undiluted and unused enzyme should be refrozen quickly by, for example, snap-freezing in a dry ice ethanol bath or liquid nitrogen. Aliquot product shall be stored -80°C. Avoid repeated freeze/defrost cycles.NOTE: When stored under the above conditions, this enzyme is stable at the concentration supplied, in its current storage buffer. Procedures such as dilution of the enzyme followed by refreezing could lead to loss of activity.
Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Screening of novel DPP-IV inhibitory peptides derived from bovine milk proteins using a peptide array platform: S. Arai, et al.; J. Biosci. Bioeng. 23, 1389 (2023), Abstract
Protease activated‐receptor 2 is necessary for neutrophil chemorepulsion induced by trypsin, tryptase, or dipeptidyl peptidase IV: M.J.V. White, et al.; J. Leukoc. Biol. 103, 119 (2018), Abstract — Full Text
Design and synthesis of aminocoumarin derivatives as DPP-IV inhibitors and anticancer agents: R. Soni, et al.; Bioorg. Chem. 79, 277 (2018), Abstract
In vitro screening for protein tyrosine phosphatase 1B and dipeptidyl peptidase IV inhibitors from selected Nigerian medicinal plants: Y. Saidu, et al.; J. Intercult. Ethanopharmacol. 2016, 154 (2016), Abstract — Full Text
Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo: S. Kim, et al.; Eur. J. Pharmacol. 788, 54 (2016), Application(s): Enzyme Inhibition assay (in vitro), Abstract

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