DPN

BML-GR248

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Estrogen receptor β activator

Selective estrogen receptor ERβ agonist displaying 70-fold greater selectivity over ERα(EC₅₀ = 0.85 and 66nM, respectively). It displays neuroprotective activity in various in vitro and in vivo models.

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Product Details

Alternative Name	Diarylpropionitrile, 2,3-bis(4-Hydroxyphenyl)-propionitrile
Appearance	White solid.
CAS	1428-67-7
Couple Target	Estrogen receptor
Couple Type	Activator, Ligand
Formula	C₁₅H₁₃NO₂
MW	239.3
MeltingPoint	197-199°C
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml) or 100% ethanol (1.5mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at-20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Neuroprotective properties of selective estrogen receptor agonists in cultured neurons: M. Cordey & C.J. Pike; Brain Res. 1045, 217 (2005), Abstract
Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia: H.V. Carswell, et al.; Am. J. Physiol. Heart Circ. Physiol. 287, H1501 (2004), Abstract
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues: M.J. Meyers, et al.; J. Med. Chem. 44, 4230 (2001), Abstract

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DPN

BML-GR248

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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