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Doxycycline . hyclate

ALX-380-273

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MMP inhibitor

Broad spectrum antibiotic and bacteriostatic. Shows antiprotozoal properties. Potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Inhibits collagen synthesis. Increases and promotes smooth muscle cell adhesion. Inhibits proliferation and migration. Protects microvasculature by inhibiting plasminogen systems.

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Product Details

Alternative Name	Doxycycline . hydrochloride . hemiethanolate . hemihydrate
Appearance	Yellow crystalline solid.
CAS	24390-14-5
Couple Target	MMP
Couple Type	Inhibitor
Formula	C₄₆H₅₈Cl₂N₄O₁₈
MI	14: 3440
MW	1025.87 g/mol
Purity	≥98% (HPLC)
RTECS	QI8925000
Solubility	Soluble in water (50mg/ml).
Source	Semisynthetic from oxytetracycline.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer: J. Namkaew, et al.; Cancer Lett. 582, 216509 (2024), Abstract
AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer: Kim, S., Au, C. C., et al.; Elife 11, (2022), Abstract
The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase: K.A. Wittig, et al.; Nucleic Acids Res. 49, 10507 (2021), Abstract
Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway: M. Wang, et al.; Cell Death Dis. 5, 153 (2019), Abstract — Full Text
A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage: Sharir, A., Marangoni, P., et al.; Nat. Cell Biol. 21, 1102 (2019), Abstract
Quantitative Clonal Analysis and Single-Cell Transcriptomics Reveal Division Kinetics, Hierarchy, and Fate of Oral Epithelial Progenitor Cells: Jones, K. B., Furukawa, S., et al.; Cell Stem Cell 24, 183 (2019), Abstract
Novel pharmacologic targeting of tight junctions and focal adhesions in prostate cancer cells: Hensley, P. J., Desiniotis, A., et al.; PLoS One 9, e86238 (2014), Abstract
Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia: D. Burggraf, et al.; Neurobiol. Dis. 25, 506 (2007), Abstract
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices: C. Franco, et al.; Am. J. Pathol. 168, 1697 (2006), Abstract — Full Text
Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry: R.A. Garcia, et al.; Mol. Pharmacol. 67, 1128 (2005), Abstract — Full Text

Last modified: May 29, 2024

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Doxycycline . hyclate

ALX-380-273

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