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Topoisomerase inhibitor
A broad spectrum antitumor agent. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Binds covalently to DNA. Inhbibits reverse transcriptase, RNA polymerase and the catalytic activity of Dnmt1. Immunosuppressive. Antineoplastic. Induces apoptosis. Down regulates c-myc and c-jun in doxorubicin-sensitive cells.
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Product Details
| Alternative Name |
DXR . HCl, 14-Hydroxydaunomycin . HCl, Adriamycin . HCl |
|---|---|
| Appearance |
Red solid. |
| CAS |
25316-40-9 |
| Couple Target |
c-Jun, c-Myc, DNA, Dnmt, Reverse transcriptase, Topoisomerase |
| Couple Type |
Inhibitor, Ligand |
| Formula |
C27H29NO11 . HCl |
| MI |
14: 3439 |
| MW |
580.0 |
| Purity |
≥95% (HPLC) |
| RTECS |
QI9295900 |
| Solubility |
Soluble in water. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Long Term Storage |
Ambient |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury: N. Kayagaki, et al.; Nature 618, 1072 (2023), Abstract
- Relative refractoriness of breast cancer cells to tumour necrosis factor-α induced necroptosis: B. Thakur, et al.; Clin. Exp. Pharmacol. Physiol. 49, 1294 (2022), Abstract
- Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases: A. Fijalkowska, et al.; Sci. Rep. 10, 20081 (2020), Abstract — Full Text
- High-affinity mutant Interleukin-13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma: Kim, G. B., Aragon-Sanabria, V., et al.; Bioact. Mater. 5, 624 (2020), Abstract
- VEGF-A/Neuropilin 1 Pathway Confers Cancer Stemness via Activating Wnt/β-Catenin Axis in Breast Cancer Cells: L. Zhang, et al.; Cell. Physiol. Biochem. 44, 1251 (2017), Abstract — Full Text
- Mcl-1 is a key regulator of the ovarian reserve: S. Omari, et al.; Cell. Death Dis. 6, e1755 (2015), Application(s): Cell Culture, Abstract — Full Text
- WIP1 phosphatase as a potential therapeutic target in neuroblastoma: Richter, M., Dayaram, T., et al.; PLoS One 10, e0115635 (2015), Abstract
- Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) to Monitor Compound Effects on Cardiac Myocyte Signaling Pathways: Guo, L., Eldridge, S., et al.; Curr. Protoc. Chem. Biol. 7, 141 (2015), Application(s): In Vitro, Abstract
- Influence of survivin-targeted therapy on chemosensitivity in the treatment of acute myeloid leukemia: Huang, J., Lyu, H., et al.; Cancer Lett. 366, 160 (2015), Abstract
- PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al.; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract — Full Text
- Examining the protective role of ErbB2 modulation in human-induced pluripotent stem cell-derived cardiomyocytes: Eldridge, S., Guo, L., et al.; Toxicol. Sci. 141, 547 (2014), Abstract
- The novel function of OCT4B isoform-265 in genotoxic stress: Y. Gao, et al.; Stem Cells 30, 665 (2012), Abstract — Full Text
- A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity: Finn, N. A., Findley, H. W., et al.; PLoS Comput. Biol. 7, e1002151 (2011), Abstract
- Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to managemen: G. Takemura & H. Fujiwara; Prog. Cardiovasc. Dis. 49, 330 (2007), Review, Abstract
- Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis: K.B. Wallace; Cardiovasc. Toxicol. 7, 101 (2007), Review, Abstract
- The power and potential of doxorubicin-DNA adducts: S.M. Cutts, et al.; IUBMB Life 57, 73 (2005), Review, Abstract
- Characterization of Adriamycin-Induced G2 Arrest and Its Abrogation by Caffeine in FL-Amnion Cells with or without p53: Y. Minemoto, et al.; Exp. Cell Res. 262, 37 (2001), Abstract
- Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin: X.X. Wu, et al.; Cancer Res. 60, 2912 (2000), Abstract
- Involvement of cyclin-dependent kinases in doxorubicin-induced apoptosis in human tumor cells: Y. Lu, et al.; Mol. Carcinog. 29, 1 (2000), Abstract
- Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000), Abstract — Full Text
- Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells: S. Gamen, et al.; Exp. Cell Res. 258, 223 (2000), Abstract
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin: D.A. Gewirtz; Biochem. Pharmacol. 57, 727 (1999), Abstract
- Doxorubicin-induced alterations of c-myc and c-jun gene expression in rat glioblastoma cells: role of c-jun in drug resistance and cell death: P. Pourquier, et al.; Biochem. Pharmacol. 55, 1963 (1998), Abstract
- Characterization of covalent adriamycin-DNA adducts: S.M. Zeman, et al.; Proc. Natl. Acad. Sci. USA 95, 11561 (1998), Abstract
- Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor: O. Katoh, et al.; Cancer Res. 58, 5565 (1998), Abstract
- Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin: D.J. Taatjes, et al.; J. Med. Chem. 39, 4135 (1996), Abstract
- Adriamycin and daunomycin induce programmed cell death (apoptosis) in tumour cells: A. Skladanowski & J. Konopa; Biochem. Pharmacol. 46, 375 (1993), Abstract
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