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Dorsomorphin . hydrochloride

ENZ-CHM141

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Potent and selective AMPK inhibitor.

Potent and selective AMPK inhibitor. Dorsomorphin also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK-2), BMPR-IA (ALK-3), and BMPR-IB (ALK-6).

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Product Details

Alternative Name	6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine dihydrochloride
Appearance	Light yellow powder solid.
CAS	1219168-18-9
Couple Target	Activin receptor, AMPK, BMP receptor
Couple Type	Inhibitor
Formula	C₂₄H₂₅N₅O . 2 HCl
MW	472.4
Purity	≥99% (HPLC)
Solubility	Soluble in DMSO or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution: de Faria, F. W., Riedel, N. C., et al.; Nat. Commun. 16, 5394 (2025), Abstract
A temporal Ca 2+-desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKß/PP2A pathways: T. Kitazawa, et al.; Am. J. Physiol. Cell Physiol. 321, C549 (2021), Abstract
A rare human CEP290 variant disrupts the molecular integrity of the primary cilium and impairs Sonic Hedgehog machinery: M.B.C. Kilander, et al.; Sci. Rep. 8, 17355 (2018), Abstract — Full Text
Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation: Dexheimer, V., Gabler, J., et al.; Sci. Rep. 6, 36655 (2016), Abstract

Last modified: May 29, 2024

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Dorsomorphin . hydrochloride

ENZ-CHM141

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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