Marine natural product from the sea hare Dolabella auricularia. Noncompetitively inhibits binding of vincristine to tubulin but has been shown to bind to the RZX/MAY region. Inhibits microtubule assembly and induces apoptosis and Bcl-2 phosphorylation in several malignant cell types.
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Regulatory Status |
RUO – Research Use Only |
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