Docetaxel

BML-T129

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Ultra-pure; stabilizes microtubules

Docetaxel is taxane-type antineoplastic agent structurally similar to taxol. It reversibly binds to polymerized tubulin inhibiting depolymerization. It induces apoptosis in a large number of tumor cells and is a clinically important anticancer agent.

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Product Details

Alternative Name	Taxotere
Appearance	White solid.
CAS	114977-28-5
Formula	C₄₃H₅₃NO₁₄
MW	807.9
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Macrophage secretory IL-1β promotes docetaxel resistance in head and neck squamous carcinoma via SOD2/CAT ICAM1 signalin: C.Y Hsieh, et al.; JCI Insight 7, e157285 (2022), Abstract
Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression: A.R. Harris, et al.; BMC Cancer 18, 718 (2018), Abstract — Full Text
Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers: Peng, X., Chen, Z., et al.; Cell Rep. 23, 255 (2018), Abstract
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract
Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells: Okita, R., Wolf, D., et al.; PLoS One 10, e0139809 (2015), Abstract
Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis: Brown, S. G., Knowell, A. E., et al.; Prostate 75, 266 (2015), Abstract
Docetaxel in the management of prostate cancer: current standard of care and future directions: S. De Dosso & D.R. Berthold; Expert. Opin. Pharmacother. 9, 1969 (2008), Abstract
Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells: F. Fabbri, et al.; J. Cell Physiol. 217, 494 (2008), Abstract
Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts: A. Cumashi, et al.; Cancer Lett. 270, 229 (2008), Abstract
RPN2 gene confers docetaxel resistance in breast cancer: K. Honma, et al.; Nat. Med. 14, 939 (2008), Abstract

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Last modified: May 29, 2024

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Docetaxel

BML-T129

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