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Dnmt3a (mouse) monoclonal antibody (64B1446)

ALX-804-370

11 citations

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Dnmt3a (mouse) monoclonal antibody (64B1446) Western blot

Product Details

Alternative Name	DNA methyltransferase-3a
Application	ChIP, ICC, IHC, IP, WB
Clone	64B1446
Crossreactivity	Weakly cross-reacts with human Dnmt3a.
Formulation	Liquid. In PBS containing 0.05% sodium azide
Host	Mouse
Immunogen	Recombinant mouse Dnmt3a (DNA methyltransferase-3a).
Isotype	IgG1
Purity Detail	Protein G-affinity purified.
Recommendation Dilutions/Conditions	Immunocytochemistry (5µg/ml)Immunohistochemistry (1:400)Western Blot (2µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Mouse
Specificity	Recognizes C-terminal epitope aa 705-908 of mouse Dnmt3a.
UniProt ID	O88508
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.: Gentry, C., Denk, F., et al.; Front. Mol. Neurosci. 11, 332 (2018), Application(s): WB / Reactant(s): Mouse, Abstract
Dnmt3a2: a hub for enhancing cognitive functions: Oliveira, A. M., Hemstedt, T. J., et al.; Mol. Psychiatry 21, 1130 (2016), Abstract
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS: Wong, M., Gertz, B., et al.; Front. Cell. Neurosci. 7, 279 (2014), Abstract
De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2’-deoxycytidine: M. Oka, et al.; Oncogene 24, 3091 (2005), Abstract
Myc represses transcription through recruitment of DNA methyltransferase corepressor: C. Brenner, et al.; EMBO 24, 336 (2005), Abstract
Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model: J.M. Stempak, et al.; Carcinogenesis 26, 981 (2005), Abstract
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system: J. Feng, et al.; J. Neurosci. Res. 79, 734 (2005), Abstract
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer: Y.W. Leu, et al.; Cancer Res. 64, 8184 (2004), Abstract
Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin: Q. Yan, et al.; Mol. Cell. Biol. 23, 8416 (2003), Abstract — Full Text
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation: T. Chen, et al.; J. Biol. Chem. 277, 38746 (2002), Abstract

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Dnmt3a (mouse) monoclonal antibody (64B1446)

ALX-804-370

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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