DMNQ

ALX-420-027

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Inducer of intracellular ROS generation

Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. DMNQ does not react with free thiol groups, is non-alkylating and adduct-forming in contrast to other quinones. Thus, DMNQ is a valuable tool for the generation of reactive oxygen species (ROS) in order to study the role of ROS in cell toxicity, apoptosis and necrosis.

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Product Details

Alternative Name	2,3-Dimethoxy-1,4-naphthoquinone
Appearance	Yellow crystalline solid.
CAS	6956-96-3
Couple Target	ROS
Couple Type	Activator
Formula	C₁₂H₁₀O₄
Identity	Determined by NMR.
MW	218.2
Purity	≥99% (TLC)
Solubility	Soluble in acetone, DMSO or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Iron deficiency aggravates DMNQ-induced cytotoxicity via redox cycling in kidney-derived cells: D. Yoshihara, et al.; Free Radic. Res. 56, 544 (2022), Abstract
A CRISPR screen identifies a pathway required for paraquat-induced cell death: C.R. Reczek, et al.; Nat. Chem. Biol. 13, 1274 (2017), Abstract — Full Text
Effects of β-Carotene and Its Cleavage Products in Primary Pneumocyte Type II Cells: Haider, C., Ferk, F., et al.; Antioxidants (Basel) 6, (2017), Abstract
The Bioenergetic Health Index is a Sensitive Measure of Oxidative Stress in Human Monocytes: B.K. Chacko, et al.; Redox Biol. 8, 43 (2015), Application(s): Inhibited mitochondrial function in human monocytes, Abstract
Oxidative stress promotes polarization of human T cell differentiation toward a T helper 2 phenotype: M.R. King, et al.; J. Immunol. 176, 2765 (2006), Abstract — Full Text
The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets: S.A. Seung, et al.; Chem. Biol. Interact. 113, 133 (1998), Abstract
Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells: K.F. Beck, et al.; FEBS Lett. 435, 35 (1998), Abstract
DNA single-strand breakage in mammalian cells induced by redox cycling quinones in the absence of oxidative stress: W.A. Morgan; J. Biochem. Toxicol. 10, 227 (1995), Abstract
Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells: J.M. Dypbukt, et al.; J. Biol. Chem. 269, 30553 (1994), Abstract — Full Text

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DMNQ

ALX-420-027

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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