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DL-α-Difluoromethylornithine . hydrochloride . monohydrate

ALX-270-283

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Inhibitor of ornithine decarboxylase and arginase

Specific, irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Potent chemopreventive agent. Induces apoptosis. Arginase activity inhibitor.

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Product Details

Alternative Name	DFMO . HCl . H2O, Eflornithine . HCl . H2O, RMI-71782
Appearance	White to off-white solid.
CAS	96020-91-6
Couple Target	Arginase, Ornithine decarboxylase
Couple Type	Inhibitor
Formula	C₆H₁₂F₂N₂O₂. HCl . H₂O
MI	14: 3522
MW	236.6
Purity	≥98% (TLC)
Solubility	Soluble in water (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme: Z. Urban-Wójciuk, et al.; Cancer Gene Ther. 10, 1038 (2021), Abstract
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses: Alsaleh, G., Panse, I., et al.; Elife 9, (2020), Abstract
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation: Puleston, D. J., Buck, M. D., et al.; Cell Metab. 30, 352 (2019), Abstract
alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model: Y. Takahashi, et al.; Int. J. Cancer 85, 243 (2000), Abstract
Development of difluoromethylornithine (DFMO) as a chemoprevention agent: F.L. Meyskens, Jr. & E.W. Gerner; Clin. Cancer Res. 5, 945 (1999), (Review), Abstract — Full Text
Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells: M. Selamnia, et al.; Biochem. Pharmacol. 55, 1241 (1998), Abstract
Difluoromethylornithine (DFMO), an inhibitor of nitrite production by macrophages?: D.M. Morgan; Biochem. Soc. Trans. 22, 389S (1994), Abstract
The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity: M.A. Markwell, et al.; Eur. J. Pharmacol. 182, 607 (1990), Abstract
Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase: A.K. Verma; Basic Life Sci. 52, 195 (1990), (Review), Abstract
The enzyme-activated irreversible inhibitor of ornithine decarboxylase, DL-alpha-difluoromethylornithine: a chemopreventive agent: A.K. Verma; Prev. Med. 18, 646 (1989), Abstract

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DL-α-Difluoromethylornithine . hydrochloride . monohydrate

ALX-270-283

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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