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DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol

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Glucosylceramide synthetase inhibitor

Inhibits glucosylceramide synthetase. More effective than PDMP in intact cells.

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Alternative Name	DL-PPMP
Appearance	White-pink solid.
CAS	149022-18-4
Couple Target	Glucosylceramide synthetase
Couple Type	Inhibitor
Formula	C₂₉H₅₀N₂O₃ . HCl
MW	511.2
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Cold Atmospheric Plasma Triggers Apoptosis via the Unfolded Protein Response in Melanoma Cells: T. Zimmermann, et al.; Cancers (Basel) 15, 1064 (2023), Abstract
Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells: A.V. Meléndez, et al.; Cell. Mol. Life Sci. 79, 513 (2022), Abstract
Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons: Shen, W., Henry, A. G., et al.; J. Neurochem. 129, 884 (2014), Abstract

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