DL-AP5

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NMDA receptor antagonist

Potent and selective NMDA receptor antagonist.

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Alternative Name	DL-2-Amino-5-phosphonopentanoic acid, DL-2-Amino-5-phosphonovaleric acid
Appearance	White to off-white powder.
CAS	76326-31-3
Couple Target	NMDA receptor
Couple Type	Inhibitor, Ligand
Formula	C₅H₁₂NO₅P
MW	197.1
Purity	≥99% (HPLC, TLC)
Solubility	Soluble in 100mM NaOH or 25mM water.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors: J.J. Hansen & P. Krogsgaard-Larsen; Med. Res. Rev. 10, 55 (1990), Abstract
The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations: R.H. Evans, et al.; Br. J. Pharmacol. 75, 65 (1982), Abstract
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4- phosphonobutyrate in the cat spinal cord: J. Davies and J.C. Watkins; Brain Res. 235, 378 (1982), Abstract
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation: J. Davies, et al.; Neurosci. Lett. 21, 77 (1981), Abstract
Excitatory amino acid transmitters: J.C. Watkins and R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review), Abstract

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