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Diprotin A

ALX-260-036

8 citations

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DPP4 inhibitor

Inhibitor of dipeptidyl aminopeptidase IV.

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Product Details

Alternative Name	H-Ile-Pro-Ile-OH
Appearance	White to off-white solid.
Application Notes	May be used to inhibit GLP-1 breakdown in blood, plasma and serum samples at a concentration of 100 µM.
CAS	90614-48-5
Formula	C₁₇H₃₁N₃O₄
MW	341.5
Purity	≥98% (HPLC)
Solubility	Soluble in water (1mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The postprandial secretion of peptide YY1-36 and 3-36 in obesity is differentially increased after gastric bypass versus sleeve gastrectomy: A.M. Kowalka, et al.; Clin. Endocrinol. 99, 272 (2023), Abstract
Sex-specific differences in metabolic outcomes after sleeve gastrectomy and intermittent fasting in obese middle-aged mice: Emiliano, A. B., Lopatinsky, N. R., et al.; Am. J. Physiol. Endocrinol. Metab. 323, E107 (2022), Abstract
Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling: M. Capitano, et al.; J. Clin. Invest. 129, 2555 (2019), Abstract — Full Text
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig: C.F. Deacon, et al.; Diabetes 47, 764 (1998), Abstract — Full Text
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum: R. Mentlein, et al.; Eur. J. Biochem. 214, 829 (1993), Abstract — Full Text
Murine thymocytes possess specific cell surface-associated exoaminopeptidase activities: preferential expression by immature CD4- CD8- subpopulation: B. Bauvois; Eur. J. Immunol. 20, 459 (1990), Abstract
Purification and some properties of a membrane-bound dipeptidyl peptidase IV of guinea pig casein-induced intraperitoneal leukocytes: M. Kudo, et al.; J. Biochem. 97, 1211 (1985), Abstract
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria: H. Umezawa, et al.; J. Antibiot. 37, 422 (1984), Abstract

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Diprotin A

ALX-260-036

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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