DIPPMPO

ALX-430-119

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Spin trapping reagent

Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090). More lipophilic (Kp=2.1) than DEPMPO.

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Product Details

Alternative Name	5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
Appearance	Off-white to pale yellow low melting solid.
Formula	C₁₁H₂₂NO₄P
MW	263.3
Purity	≥98% (TLC, 1H- and 13C-NMR)
Solubility	Soluble in water, 100% ethanol or methylene chloride.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Very hygroscopic. Handle under an inert atmosphere.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The Role of Chelating Agents and Amino Acids in Preventing Free Radical Formation in Bleaching Systems: J. Hodes, et al.; Free Radic. Biol. Med. 129, 194 (2018), Abstract
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis: Kalucka, J., Bierhansl, L., et al.; Cell Metab. 28, 881 (2018), Abstract
Study of natural anthraquinone colorants by EPR and UV/vis spectroscopy: Z. Machatova, et al.; Dyes Pigm. 132, 79 (2016), Application(s): Cell culture
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus: Y. Shi, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 304, R343 (2013), Application(s): Electron paramagnetic resonance (EPR) spectroscopy, Abstract — Full Text
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO: M. Culcasi, et al.; Free Radic. Biol. Med. 40, 1524 (2006), Abstract
5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties: F. Chalier & P. Tordo; J. C. S. Perkin Trans. II 2002, 2110 (2002), Full Text

Related Products

DMPO

ALX-430-090

Spin trapping reagent

48 citations

Alternative Name	5,5-Dimethyl-1-pyrroline-N-oxide, 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide
CAS	3317-61-1
Purity	>98% (HPLC)

DEPMPO

ALX-430-093

Spin trapping reagent

37 citations

Alternative Name	5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, 2-Diethylphosphono-2-methyl-3,4-dihydro-2H-pyrrole 1-oxide, (2-Methyl-3,4-dihydro-1-oxide-2H-pyrrol-2-yl)diethylphosphonate
CAS	157230-67-6
Purity	≥99% (TLC)

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DIPPMPO

ALX-430-119

Product Details

Handling & Storage

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