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Diphtheria toxin (Corynebacterium diphtheriae)

BML-G135

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Elongation factor 2 (EF-2) catalyzes the GTP hydrolysis-dependent translocation reaction that is responsible for the movement of the ribosome along mRNA during protein synthesis. Diphtheria toxin catalyzed ADP-ribosylation of EF-2 inhibits the translocation reaction which halts protein synthesis and ultimately results in cell death. Diphtheria toxin is cell permeable and can translocate across endosomal membranes in response to low pH3.

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Product Details

Formulation	Lyophilized.
Reconstitution	Reconstitute with 0.5mL of sterile distilled water
Source	From Corynebacterium diphtheriae.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Development of a bead-based multiplex immunoassay for simultaneous quantitative detection of IgG serum antibodies against seven vaccine-preventable diseases: E.N. Bykonia, et al.; J. Immunol. Methods 512, 113408 (2023), Abstract
PD-L1 checkpoint blockade promotes regulatory T cell activity that underlies therapy resistance: van Gulijk, M., van Krimpen, A., et al.; Sci. Immunol. 8, eabn6173 (2023), Abstract
Smooth muscle contributes to the development and function of a layered intestinal stem cell niche: McCarthy, N., Tie, G., et al.; Dev. Cell 58, 550 (2023), Abstract
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity: A.T. Krishnamurty, et al.; Nature 611, 148 (2022), Abstract
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota: X. Liu, et al.; Nat. Immunol. 23, 1564 (2022), Abstract
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues: V. Kapoor, et al.; Nat. Immunol. 22, 571 (2021), Abstract
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient: McCarthy, N., Manieri, E., et al.; Cell Stem Cell 26, 391 (2020), Abstract
Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy: Dominguez, C. X., Müller, S., et al.; Cancer Discov. 10, 232 (2020), Abstract
Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis: Wen, H. J., Gao, S., et al.; Cell. Mol. Gastroenterol. Hepatol. 8, 173 (2019), Abstract
Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo: O. Sonzogni, et al.; PLOS Biol. 16, e2004049 (2018), Abstract

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Diphtheria toxin (Corynebacterium diphtheriae)

BML-G135

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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