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Dimethyloxaloylglycine

BML-EI347

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Prolyl-4-hydroxylase inhibitor

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

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Product Details

Alternative Name	DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester
Appearance	Off-white solid.
CAS	89464-63-1
Couple Target	FIH, HIF, Prolyl-4-hydroxylase
Couple Type	Activator, Inhibitor
Formula	C₆H₉NO₅
MW	175.1
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml) or dimethyl formamide; soluble also in PBS, pH7.2 (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway: T. Ocklenburg, et al.; Sci. Rep. 11, 7199 (2021), Abstract — Full Text
Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo: Lewis, A., Elks, P. M., et al.; Front. Immunol. 10, 2321 (2019), Abstract
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation: J.A. Maybin, et al.; Nat. Commun. 9, 295 (2018), Abstract — Full Text
The Chorioallantoic Membrane of the Chick Embryo to Assess Tumor Formation and Metastasis: A. Hermann, et al.; Methods Mol. Biol. 1464, 97 (2016), Abstract
Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter: A. Salvi & T. Thanabalu; Biochem. Biophys. Rep. 9, 13 (2016), Abstract — Full Text
Loss of HIF-1α in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model: N. Henke, et al.; Oncotarget. 7, 25915 (2016), Application(s): Cell culture and incubation, bone-marrow-derived and peritoneal macrophages, Abstract — Full Text
Mutant versions of von Hippel-Lindau (VHL) can protect HIF1α from SART1-mediated degradation in clear-cell renal cell carcinoma: A. Ordóñez-Navadijo, et al.; Oncogene 35, 587 (2016), Application(s): Inhibition Assay, Abstract
Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate: Limani, P., Linecker, M., et al.; Clin. Cancer Res. 22, 5887 (2016), Abstract
Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells: T.M. Asikainen, et al.; Free Radic. Biol. Med. 38, 1002 (2005), Abstract
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung: T.M. Asikainen, et al.; Proc. Natl. Acad. Sci. USA 102, 10212 (2005), Abstract

Last modified: May 29, 2024

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Dimethyloxaloylglycine

BML-EI347

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Handling & Storage

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