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Diindolylmethane

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Ah receptor antagonist

A partial antagonist for the aryl hydrocarbon receptor. Induces apoptosis in human cancer cells. Activates cytochrome P-450 1A2.

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Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E. V. Hestermann & M. Brown; Mol. Cell. Biol. 23, 7920 (2003), Abstract — Full Text
3,3′-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B. G. Lake, et al.; Xenobiotica 28, 803 (1998), Abstract
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol. 51, 1069 (1996), Abstract

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