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Dihydrosphingosine, D-erythro

BML-SL125

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Sphingosine precursor

Biosynthetic precursor of sphingosine. Inhibitor of protein kinase C (PKC). Blocks phospholipases A₂ (PLA2) and the D-sphingosine precursor.

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Product Details

Alternative Name	D-erythro-Sphingosine, Dihydro-, Sphinganine
Appearance	White to off-white solid.
CAS	764-22-7
Couple Target	Phospholipase, PKC, PLA
Couple Type	Inhibitor
Formula	C₁₈H₃₉NO₂
MW	301.5
Purity	≥98% (TLC)
Solubility	Soluble in 100% ethanol (25mg/ml, warm) or DMSO (25mg/ml, warm).
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases: T. Narita, et al.; Sci. Rep. 6, 25469 (2016), Application(s): Cell culture, Abstract — Full Text
The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity: A. Kempf, et al.; PLoS Biol. 12, e1001763 (2014), Application(s):Treatment of 3T3 cells, Abstract — Full Text
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60): B.Y. Yung, et al.; BBRC 199, 888 (1994), Abstract
Glucocorticoid stimulation of amnion cell prostaglandin synthesis: suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C: T. Zakar, et al.; Biochim. Biophys. Acta 1136, 161 (1992), Abstract
Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine: R.C. Franson, et al.; Biochim. Biophys. Acta 1136, 169 (1992), Abstract
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds: A.H. Merrill, Jr., et al.; Biochemistry 28, 3138 (1989), Abstract
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s): A.H. Merrill & E. Wang; J. Biol. Chem. 261, 3764 (1986), Abstract
In vivo studies on the introduction of the 4-t-double bond of the sphingenine moiety of rat brain ceramides: D.E. Ong & R.N. Brady; J. Biol. Chem. 248, 3884 (1973), Abstract

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Last modified: May 29, 2024

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Dihydrosphingosine, D-erythro

BML-SL125

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