DIF-1

BML-GR324

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Ultra-pure; Induces cell differentiation

Supresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60 cells. It is a known inhibitor of Wnt/β-Catenin signaling pathway.

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Product Details

Alternative Name	1-(3,5-Dichloro-2,6-dihydroxy-4-methoxyphenyl) hexan-1-one, Differentiation-inducing factor-1
Appearance	Pale yellow solid.
CAS	111050-72-7
Couple Target	Wnt
Couple Type	Inhibitor
Formula	C₁₃H₁₆Cl₂O₄
MW	307.2
Purity	≥98% (HPLC)
Solubility	Soluble in ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Evolution of a novel cell type in Dictyostelia required gene duplication of a cudA-like transcription factor: K. Kin, et al.; Curr. Biol. , S0960 (2021), Abstract
Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning: Gruenheit, N., Parkinson, K., et al.; Dev. Cell 47, 494 (2018), Abstract
Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1: J. Calvo-Garrido & R. Escalante; Autophagy 6, 99 (2010), Abstract
DIF-1, putative morphogen of D. discoideum, suppresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60: Y. Kubohara, et al.; Biochem. Biophys. Res. Commun. 236, 418 (1997), Abstract

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DIF-1

BML-GR324

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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