Home Shop Diethyldithiocarbamic acid . sodium salt . trihydrate (high purity)

Diethyldithiocarbamic acid . sodium salt . trihydrate (high purity)

ALX-400-003

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NO spin trapping reagent

Nitric oxide (NO) spin-trapping reagent. Thiol and iron chelator. Inhibits induction of macrophage nitric oxide synthase (NOS). Has been shown to be an inhibitor of the nuclear transcription factor κB (NF-κB).

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Product Details

Alternative Name	DETC . 3H2O (high purity), Diethyldithiocarbamate . 3H2O (high purity)
Appearance	White to off-white solid.
CAS	20624-25-3
Couple Target	NF-kappaB
Couple Type	Inhibitor
Formula	C₅H₁₀NS₂ . Na . 3H₂O
MI	14: 3378
MW	148.3 . 23.0 . 54.0
Purity	≥99% (Titration)
RTECS	EZ6550000
Solubility	Soluble in water (20mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Effect of early acute high concentrations of iodide exposure on mitochondrial superoxide production in FRTL cells: X. Yao, et al.; Free Radic. Biol. Med. 52, 1343 (2012), Abstract
Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes: Kwong, C., Gilman-Sachs, A., et al.; J. Immunol. 186, 1781 (2011), Abstract
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006), Abstract
EPR quantification of vascular nitric oxide production in genetically modified mouse models: J.P. Khoo, et al.; Nitric Oxide 10, 156 (2004), Abstract
EPR spectroscopy of common nitric oxide – spin trap complexes: S. Nedeianu & T. Pali; Cell Mol. Biol. Lett. 7, 142 (2002), Abstract
Ex vivo EPR detection of nitric oxide in brain tissue: H. Fujii & L.J. Berliner; Magn. Reson. Med. 42, 599 (1999), Abstract
NO-dependent mechanisms of adaptation to hypoxia: I.Y. Malyshev, et al.; Nitric Oxide 3, 105 (1999), Abstract
Iron diethyldithiocarbamate as spin trap for nitric oxide detection: A.F. Vanin; Methods Enzymol. 301, 269 (1999), Review, Abstract
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997), Abstract
EPR and laser flash photolysis studies of the reaction of nitric oxide with water soluble NO trap Fe(II)-proline-dithiocarbamate complex: S.V. Paschenko, et al.; BBRC 225, 577 (1996), Abstract

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Diethyldithiocarbamic acid . sodium salt . trihydrate (high purity)

ALX-400-003

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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