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Dibutyryl-cAMP

BML-CN125

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PKA activator

Cell-permeable PKA activator
Compound used to study neurogenesis

Dibutyryl-cAMP (DB-cAMP) is a cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (e.g. protein kinase A) and inhibits phosphodiesterases. Used together with other compounds, DB-cAMP increases survival rate and promote differentiation of neural stem/progenitor cells into neurons in vivo. DB-cAMP also has anti-inflammatory properties and can be used to facilitate wound healing. Caution: Due to extra- and intra-cellular esterases, DB-cAMP releases butyrate, which may have distinct biological effects.

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Product Details

Alternative Name	Dibutyl cyclic AMP sodium salt, N6-2′-O-dibutyryladenosine-3′,5′-cyclic monophosphate, DB-cAMP
Appearance	White crystalline solid.
CAS	16980-89-5
Couple Target	PKA
Couple Type	Activator
Formula	C₁₈H₂₃N₅O₈P . Na
Identity	Identity determined by MS, 1H-NMR, 31P-NMR, and UV spectrum.
MW	491.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (200mM), 96% ethanol (25mM), or water (100mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solution must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Quantification of Neurite Degeneration with Enhanced Accuracy and Efficiency in an In Vitro Model of Parkinson’s Disease: R.T. Clements, et al.; eNeuro 9, ENEURO.0327-21.2022 (2022), Abstract
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons: Burbidge, K., Rademacher, D. J., et al.; Autophagy 18, 1020 (2022), Abstract
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin: J. Ha, et al.; Sci. Adv. 8, eabk1239 (2022), Abstract
Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons: L.F. Ornelas, et al.; NPJ Parkinsons Dis. 8, 118 (2022), Abstract
High-content phenotyping of Parkinson’s disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification: A. Vuidel, et al.; Stem Cell Reports 17, 2349 (2022), Abstract
Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons: A.M. Earley, et al.; Sci. Rep. 11, 22257 (2021), Abstract
c-Jun N-terminal Kinase Mediates Ligand-independent p75NTR Signaling in Mesencephalic Cells Subjected to Oxidative Stress: Kraemer, B. R., Clements, R. T., et al.; Neuroscience 453, 222 (2021), Abstract
Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease: J. Ha, et al.; Front Cell Dev Biol 8, 594090 (2020), Abstract
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons: C. Uberbacher, et al.; Stem Cell Res. 41, 101656 (2019), Abstract
Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro: Bakhti, M., Scheibner, K., et al.; Mol. Metab. 30, 16 (2019), Abstract