Diazoxide

ALX-550-260

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K⁺ channel activator

ATP-sensitive K⁺ channel activator. Effective concentrations in patch clamp experiments: 100-600µM. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.

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Product Details

Alternative Name	7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
Appearance	White to off-white powder.
CAS	364-98-7
Couple Target	Potassium channel
Couple Type	Activator
Formula	C₈H₇ClN₂O₂S
MI	14: 3004
MW	230.7
Purity	≥98% (HPLC)
RTECS	DK8185000
Solubility	Soluble in DMSO (25mg/ml); insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Diazoxide-sensitivity of the adenosine 5′-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol. 107, 87 (1992), Abstract
Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists: M.J. Dunne et al.; Br. J. Pharmacol. 103, 1847 (1991), Abstract
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol. 114, 53 (1990), Abstract
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol. 100, 605 (1990), Abstract
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther. 250, 261 (1989), Abstract
Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett. 250, 262 (1989), Abstract
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line: N.C. Strugess et al.; Br. J. Pharmacol. 95, 83 (1988), Abstract
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol. 407, 493 (1986), Abstract

Related Products

Pinacidil . monohydrate

ALX-550-285

K⁺ channel activator

1 citation

Alternative Name	(±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate
CAS	85371-64-8
Couple Type	Activator
Purity	≥98% (HPLC)

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Diazoxide

ALX-550-260

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