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Dexamethasone

BML-EI126

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Glucocorticoid receptor ligand

Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Furthermore, it inhibits differentiation of immature to mature dendritic cells.

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Product Details

Alternative Name	9α-Fluoro-16α-methylprednisolone
Appearance	White to off-white solid.
CAS	50-02-2
Couple Target	Glucocorticoid receptor, IDO
Couple Type	Activator, Ligand
Formula	C₂₂H₂₉FO₅
MI	14: 2943
MW	392.5
Purity	≥98% (HPLC)
RTECS	TU3980000
Solubility	Soluble in DMSO (25mg/ml), 100% ethanol (25mg/1.6ml) or methanol; insoluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 5 years after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Secreted Adipocytokines in Harvested Visceral Fat Differ over Age and Diet in Control and High-Fat Diet Fed Female C3H/Hej Mice: Mubtasim, N., Barr, B., et al.; Preprints.org , (2024)
In Vitro Investigation of 3D Printed Hydrogel Scaffolds with Electrospun Tidemark Component for Modeling Osteochondral Interface: Effanga, V. E., Akilbekova, D., et al.; Gels 10, (2024), Abstract
Characterizing 3T3-L1 MBX Adipocyte Cell Differentiation Maintained with Fatty Acids as an In Vitro Model to Study the Effects of Obesity: Mubtasim, N., Gollahon, L., et al.; Life (Basel) 13, (2023), Abstract
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response: Y. Son, et al.; Immune Netw. 23, e40 (2023), Abstract
In Vitro Tracking of Human Umbilical Vein Endothelial Cells Using Ultra-Sensitive Quantum Dot-Embedded Silica Nanoparticles: J. Kim, et al.; Int. J. Mol. Sci. 24, 5794 (2023), Abstract
Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells: M. Razavi, et al.; Sci. Adv. 7, eabf9221 (2021), Abstract
Controlled Release of Anti-Inflammatory and Proangiogenic Factors from Macroporous Scaffolds: Liang, J. P., Accolla, R. P., et al.; Tissue Eng. Part A 27, 1275 (2021), Abstract
Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish: Haney, M. G., Moore, L. H., et al.; J. Vis. Exp. , (2020), Abstract
Controlled Release of Anti-inflammatory and Pro-angiogenic Factors from Macroporous Scaffolds: Liang, J., Accolla, R. P., et al.; bioRxiv , (2020)
Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery: G.M. Nabar, et al.; Int. J. Nanomedicine 13, 351 (2018), Abstract — Full Text

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Compound A

ALX-550-516

Glucocorticoid receptor modulator

6 citations

Alternative Name	CpdA, 2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride
CAS	14593-25-0
Purity	≥98% (HPLC)

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Dexamethasone

BML-EI126

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