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Nitric oxide donor
Nitric oxide (NO) donor. Induces apoptosis in macrophages. The half-life time of DETA NONOate is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0. DETA NONOate liberates 2 mol of NO per mol of parent compound.
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Product Details
| Alternative Name |
NOC-18, DETA/NO, (Z)-1-[2-(2-Aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate, 3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene, 2,2′-(Hydroxynitrosohydrazino)bis-ethanamine |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
146724-94-9 |
| Formula |
C4H13N5O2 |
| MW |
163.2 |
| Purity |
≥97% (1H-NMR) |
| RTECS |
KH2502500 |
| Solubility |
Soluble in water or ethanol. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light and moisture. |
| Long Term Storage |
-80°C |
| Shipping |
Dry Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Ovothiol is a redundant part of a complex thiol network in promastigoteLeishmania mexicana: Bolton, V. L., Regnault, C., et al.; bioRxiv , (2023)
- Nitric oxide attenuated transforming growth factor-β induced myofibroblast differentiation of human keratocytes: J.H. Park, et al.; Sci. Rep. 11, 41598 (2021), Abstract — Full Text
- Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation: Gojkovic, M., Cunha, P. P., et al.; Front. Immunol. 12, 633586 (2021), Abstract
- Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection: P. Sarkar, et al.; Mult. Scler. , (2021), Abstract
- Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct: Curnow, A. C., Gonsalez, S. R., et al.; Front. Physiol. 11, 559341 (2020), Abstract
- S-nitrosoglutathione inhibits adipogenesis in 3T3-L1 preadipocytes by S-nitrosation of CCAAT/enhancer-binding protein β: M. Mussbacher, et al.; Sci. Rep. 9, 15403 (2019), Abstract — Full Text
- NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming: K.E. Hawkins, et al.; Cell Rep. 14, 1883 (2016), Application(s): Cell culture, Abstract
- The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes: P. Ge, et al.; Invest. Ophthalmol. Vis. Sci. 57, 1317 (2016), Application(s): Cell culture, Abstract — Full Text
- Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl: M.M. Cortese-Krott, et al.; PNAS 112, e4651 (2015), Application(s): Cell culture, Abstract — Full Text
- Novel Insights in mammalian catalase heme maturation: Effect of NO and Thioredoxin-1: R. Chakravarti, et al.; Free Radic. Biol. Med. 82, 105 (2015), Application(s): Cell Culture, Abstract
- Lipopolysaccharide induces inducible nitric oxide synthase-dependent podocyte dysfunction via a hypoxia-inducible factor 1-alpha and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathway: A.K. Mashmoushi, et al.; Free Radic. Biol. Med. 84, 185 (2015), Application(s): Cell Culture, Assay, Abstract
- Inflammatory cytokines induce MAdCAM-1 in murine hepatic endothelial cells and mediate alpha-4 beta-7 integrin dependent lymphocyte endothelial adhesion in vitro: T. Ando, et al.; BMC Physiol. 7, 10 (2007), Abstract — Full Text
- The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants: I. Sinha, et al.; Ann. Vasc. Surg. 20, 92 (2006), Abstract
- Hemodynamic effects of the nitric oxide donor DETA/NO in mice: C.G. Schyvens, et al.; Clin. Exp. Hypertens. 26, 525 (2004), Abstract
- The selective pulmonary vasodilatory effect of inhaled DETA/NO, a novel nitric oxide donor, in ARDS-a pilot human trial: C.F. Lam, et al.; J. Crit. Care 19, 48 (2004), Abstract
- Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS 101, 7630 (2004), Abstract — Full Text
- In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001), Abstract
- Protective effect of thioredoxin upon NO-mediated cell injury in THP1 monocytic human cells: P.J. Ferret, et al.; Biochem. J. 346, 759 (2000), Abstract
- Resistance to nitric oxide-mediated apoptosis in HL-60 variant cells is associated with increased activities of Cu,Zn-superoxide dismutase and catalase: M. Yabuki, et al.; Free Radic. Biol. Med. 26, 325 (1999), Abstract
- Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells: H. Muhl, et al.; Eur. J. Immunol. 29, 3225 (1999), Abstract
- In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl-penicillamine, towards cells from human oral tissue: H. Babich, et al.; Pharmacol. Toxicol. 84, 218 (1999), Abstract
- Schedule and concentration-dependent induction of apoptosis in leukemia cells by nitric oxide: P.J. Shami, et al.; Leukemia 12, 1461 (1998), Abstract
- NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages: M. Shimaoka, et al.; BBRC 209, 519 (1995), Abstract
- New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
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