DEPMPO

ALX-430-093

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Spin trapping reagent

Most efficient spin trap for the in vitro and in vivo detection of O-, N-, S- and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090). Can distinguish between superoxide-dependent and independent mechanisms that lead to the hydroxyl radical. Less lipophilic (Kp=0.16) than DIPPMPO (Prod. No. ALX-430-119).

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DEPMPO Spectrum — Spectrum of the (O^2-)-DEPMPO adduct.

Product Details

Alternative Name	5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, 2-Diethylphosphono-2-methyl-3,4-dihydro-2H-pyrrole 1-oxide, (2-Methyl-3,4-dihydro-1-oxide-2H-pyrrol-2-yl)diethylphosphonate
Appearance	Colorless to light yellow oil.
CAS	157230-67-6
Formula	C₉H₁₈NO₄P
MW	235.2
Purity	≥99% (TLC)
Solubility	Soluble in water, methylene chloride or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Unstable in solution. Reconstitute just prior to use.
Handling	Protect from light and moisture. Keep under inert gas. Hygroscopic.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Degradation Mechanisms of 4,7-Dihydroxycoumarin Derivatives in Advanced Oxidation Processes: Experimental and Kinetic DFT Study: Ž. Milanović, et al.; Int. J. Environ. Res. Public Health 20, 2046 (2023), Abstract
Nanoceria potently reduce superoxide fluxes from mitochondrial electron transport chain and plasma membrane NADPH oxidase in human macrophages: Y.R. Li, et al.; Mol. Cell. Biochem. 1007, 11010 (2022), Abstract
Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes: E.H. Avdović, et al.; Oxid. Med. Cell. Longev. 2021, 8849568 (2021), Abstract — Full Text
Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15: E.R.M. Zunica, et l.; Cancer Metab. 9, 36 (2021), Abstract
Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH: J. Korac, et al.; Sci. Rep. 8, 3530 (2018), Abstract — Full Text
Apple pectin-derived oligosaccharides produce carbon dioxide radical anion in Fenton reaction and prevent growth of Escherichia coli and Staphylococcus aureus: J. Martinov, et al.; Food Res. Int. 100, 132 (2017), Application(s): EPR spin-trapping spectroscopy, Abstract
Hydrogen Sulfide—Mechanisms of Toxicity and Development of an Antidote: J. Jiang, et al.; Sci. Rep. 6, 20831 (2016), Application(s): Recorded EPR signal, Abstract — Full Text
Photo-redox reactions of indole and ferric iron in water: S. Milić Komić, et al.; Appl. Catal. B 185, 174 (2016), Application(s): EPR spectroscopy
Cavitation during the protein misfolding cyclic amplification (PMCA) method – the trigger for de novo prion generation: C.L. Haigh & S.C. Drew; Biochem. Biophys. Res. Commun. 461, 494 (2015), Application(s): Cell Culture, Abstract
Protein Corona Prevents TiO2 Phototoxicity: M. Garvas, et al.; PLoS One 10, e0129577 (2015), Application(s): Measurement of photocatalytic activity , Abstract — Full Text

Related Products

DMPO

ALX-430-090

Spin trapping reagent

48 citations

Alternative Name	5,5-Dimethyl-1-pyrroline-N-oxide, 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide
CAS	3317-61-1
Purity	>98% (HPLC)

DIPPMPO

ALX-430-119

Spin trapping reagent

6 citations

Alternative Name	5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
Purity	≥98% (TLC, 1H- and 13C-NMR)

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DEPMPO

ALX-430-093

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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